The evolution of a national research plan for computers in education in The Netherlands

This paper describes the evolution of a national research plan for computers and education in The Netherlands. This approach was initiated in 1983 and includes two phases: one from 1984 until 1988 and one from 1989 until 1992. The paper describes the research plans for the second phase, based upon the experiences of the first, and draws some general conclusions about the development of national research plans for computers in education

Spontaneous thought and vulnerability to mood disorders : the dark side of the wandering mind

There is increasing interest in spontaneous thought, namely task-unrelated or rest-related mental activity. Spontaneous thought is an umbrella term for processes like mind-wandering, involuntary autobiographical memory, and daydreaming, with evidence elucidating adaptive and maladaptive consequences. In this theoretical framework, we propose that, apart from its positive functions, spontaneous thought is a precursor for cognitive vulnerability in individuals who are at risk for mood disorders. It is important that spontaneous thought mostly focuses on unattained goals and evaluates the discrepancy between current and desired status. In individuals who stably (i.e., trait negative affectivity) or transitorily (i.e., stress) experience negative emotions in reaction to goal-discrepancy, spontaneous thought fosters major cognitive vulnerabilities (e.g., rumination, hopelessness, low self-esteem, and cognitive reactivity), which, in turn, enhance depression. Furthermore, we also highlight preliminary links between spontaneous thought and bipolar disorder. The evidence for this framework is reviewed, and we discuss theoretical and clinical implications of our proposal

Twin-free YBa2Cu3O7 films on (001) NdGaO3 showing isotropic electrical behaviour

Investigating the epitaxial nature of YBa2Cu3O7 films on NdGaO3 (001) by Rutherford backscattering (RBS) and X-ray diffraction (XRD) texture measurements we find that the films are almost single crystalline, in the sense that the a, b and c axes are uniquely defined with respect to those of NdGaO3. The crystalline perfection is, however, not reflected in the electrical properties of the films. Although we measure a Tc of 89.7 K, we did not observe the expected anisotropy in the resistivity. We interpret this to be due to Ga diffusion from the substrate into the film, which effectively blocks the chain conductivity

Diabetes induced by gain-of-function mutations in the Kir6.1 subunit of the KATP channel

Gain-of-function (GOF) mutations in the pore-forming (Kir6.2) and regulatory (SUR1) subunits of K(ATP) channels have been identified as the most common cause of human neonatal diabetes mellitus. The critical effect of these mutations is confirmed in mice expressing Kir6.2-GOF mutations in pancreatic β cells. A second K(ATP) channel pore-forming subunit, Kir6.1, was originally cloned from the pancreas. Although the prominence of this subunit in the vascular system is well documented, a potential role in pancreatic β cells has not been considered. Here, we show that mice expressing Kir6.1-GOF mutations (Kir6.1[G343D] or Kir6.1[G343D,Q53R]) in pancreatic β cells (under rat-insulin-promoter [Rip] control) develop glucose intolerance and diabetes caused by reduced insulin secretion. We also generated transgenic mice in which a bacterial artificial chromosome (BAC) containing Kir6.1[G343D] is incorporated such that the transgene is only expressed in tissues where Kir6.1 is normally present. Strikingly, BAC-Kir6.1[G343D] mice also show impaired glucose tolerance, as well as reduced glucose- and sulfonylurea-dependent insulin secretion. However, the response to K(+) depolarization is intact in Kir6.1-GOF mice compared with control islets. The presence of native Kir6.1 transcripts was demonstrated in both human and wild-type mouse islets using quantitative real-time PCR. Together, these results implicate the incorporation of native Kir6.1 subunits into pancreatic K(ATP) channels and a contributory role for these subunits in the control of insulin secretion

Fast thermistor string observations at the slope of Great Meteor Seamount

International audienceA very fast thermistor string has been built to accommodate the scientific need to accurately monitor fast and vigorous internal wave and overturning processes above sloping bottoms in the ocean. The thermistors and their custom designed electronics can register temperature at an estimated precision of about 1mK with a response time faster than 0.25 s down to depths of 6000 m. The present string holds 128 synoptically measuring sensors at 0.5 m intervals, which are all read-out within 0.5 s. When sampling at 1Hz, the batteries and the memory capacity of the recorder allow for deployments of up to 2 weeks. Detailed examples of the first field observations are presented, which show overturning and very high-frequency (Doppler-shifted) internal waves besides occasionally large turbulent bores moving up the sloping side of Great Meteor Seamount, Canary Basin, North-Atlantic Ocean

High sampling rate thermistor string observations at the slope of Great Meteor Seamount

International audienceA high sampling rate (1 Hz) thermistor string has been built to accommodate the scientific need to accurately monitor high-frequency and vigorous internal wave and overturning processes in the ocean. The thermistors and their custom designed electronics can register temperature at an estimated precision of about 0.001° C with a response time faster than 0.25 s down to depths of 6000 m. With a quick in situ calibration using SBE 911 CTD an absolute accuracy of 0.005° C is obtained. The present string holds 128 sensors at 0.5 m intervals, which are all read-out within 0.5 s. When sampling at 1 Hz, the batteries and the memory capacity of the recorder allow for deployments of up to 2 weeks. In this paper, the instrument is described in some detail. Its performance is illustrated with examples from the first moored observations, which show Kelvin-Helmholtz overturning and very high-frequency (Doppler-shifted) internal waves besides occasionally large turbulent bores moving up the sloping side of Great Meteor Seamount, Canary Basin, North-Atlantic Ocean

Localized Control of Curie Temperature in Perovskite Oxide Film by Capping-layer- induced Octahedral Distortion

With reduced dimensionality, it is often easier to modify the properties of ultra-thin films than their bulk counterparts. Strain engineering, usually achieved by choosing appropriate substrates, has been proven effective in controlling the properties of perovskite oxide films. An emerging alternative route for developing new multifunctional perovskite is by modification of the oxygen octahedral structure. Here we report the control of structural oxygen octahedral rotation in ultra-thin perovskite SrRuO3 films by the deposition of a SrTiO3 capping layer, which can be lithographically patterned to achieve local control. Using a scanning Sagnac magnetic microscope, we show increase in the Curie temperature of SrRuO3 due to the suppression octahedral rotations revealed by the synchrotron x-ray diffraction. This capping-layer-based technique may open new possibilities for developing functional oxide materials.Comment: Main-text 5 pages, SI 6 pages. To appear in Physical Review Letter

Breaking the vise of hopelessness: Targeting its components, antecedents, and context

Hopelessness is a painful cognitive state that is related to depression and suicide. Despite its importance, only unsystematic efforts have been made to specifically target hopelessness in interventions, and no comprehensive review is currently available to guide future clinical studies. In this narrative review, we first analyze the phenomenon of hopelessness, by highlighting its components (e.g., dismal expectations, blocked goal-directed processing, and helplessness), antecedents (e.g., inferential styles), and contextual factors (e.g., loneliness and reduced social support). Then, we review the currently available interventions and manipulations that target these mechanisms, either directly or indirectly, and we highlight both their strengths and lacunae. Finally, we propose possible avenues to improve our clinical toolbox for breaking the vise of hopelessness